Studies on the biosynthesis of guanosine diphosphate L-fucose.

The kinetics of reduced triphosphopyridine nucleotide oxidation suggested that guanosine 5’.diphosphate-n-mamrose was converted to intermediates before reduction by reduced triphosphopyridine nucleotide (2). Subsequent studies revealed that the intermediates could be chemically reduced to guanosine 5’-diphosphate-6-deoxyhexoses (3). The present paper is concerned with the nature of the intermediates and the formation and identification of the reduction products.